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2016 Precision Medicine Pilot Awards – Announced February 5, 2016

Investigative Team Department Research Topic
Changchun Deng, MD, PhD (PI)
Peter Sims, PhD
Donald Landry, MD, PhD
Karthik Ganapathi, PhD
Medicine
Systems Biology
Medicine
Pathology and Cell Biology
Precision Delivery of c-Myc-Silencing Therapy by Identifying Genes Sensitive to Dual Inhibition of PI3Kδ and CK1ε
Pamela Freda, MD (PI)
Peter Canoll, MD, PhD
Jeffrey Bruce, MD
Yufeng Shen, PhD
Zhezhen Jin, PhD
Alexander Khandji, MD
Medicine
Pathology and Cell Biology
Neurosurgery
Biomedical Informatics
Biostatistics
Radiology
Development of a personalized approach to the evaluation and treatment of acromegaly: Integration of genomic, histopathologic and radiographic data with a large, existing prospective clinical outcomes dataset
Kenneth Olive, PhD (PI)
Andrea Califano, PhD
Medicine
Systems Biology
Precision targeting of pancreatic cancer regulatory networks
Simone Sanna-Cherchi, MD (PI)
Iuliana Ionite-Laza, PhD
Barry Honig, PhD, MS
Medicine
Biostatistics
Biochemistry / Molecular Biophysics
A functional modeling framework to identify actionable alleles from clinical exome sequencing
Marcella Walker, MD, MS (PI)
David Goldstein, PhD
Edward Guo, PhD, MS
Xiaolin Zhu, MB
Medicine
Genetics and Development
Biomedical Engineering
Institute for Genomic Medicine
A genetic approach toward individualizing the assessment of osteoporosis

2015 Precision Medicine Pilot Awardees – Announced December 10, 2014

Collaborators Department Research Topic
Ying Kuen K. Cheung, PhD (PI)
Joseph Jurcic, MD
Shing Lee, PhD
Min Qian, PhD
Gary Schwartz, MD
Biostatistics
Medicine
Biostatistics
Biostatistics
Medicine
Model Enrichment in Reinforcement Learning for Optimal Personalized and Patient Centered Cancer Treatments
Thomas Diacovo, MD (PI)
Samuel Sia, PhD
Pediatrics
Biomedical Engineering
Personalized Pharmacology for Neonatal Cardiac Patients at Risk for Arterial Thrombotic Events
Krzysztof Kiryluk, MD, MS (PI)
David J. Cohen, MD
Vivette D. D’Agati, MD
Jean C. Emond, MD
Susan Restaino, MD
Elizabeth Verna, MD
Chunhua Weng, PhD
Emmanuel Zorn, PhD
Medicine
Medicine
Pathology and Cell Biology
Surgery
Medicine
Medicine
Bioinformatics
Medicine
Donor-Recipient Genomic Incompatibilities in Solid Organ Transplant
Heath Morris, MD (PI)
Yufeng Shen, PhD
Megan Sykes, MD
Medicine
Biomedical Informatics
Medicine
A New Biomarker of Kidney Transplant Outcomes: Tracking the Fate of Donor-Reactive T Cells in the Blood and Urine
Ruth Ottman, PhD (PI)
Cigdem Inan Akman, MD
Hyunmi Choi, MD, MS
Arthur Jeff Goldsmith, PhD
Dale C. Hesdorffer, PhD
Karolynn Siegel, PhD
Annapurna Poduri, MD, PhD
Epidemiology
Neurology
Neurology
Biostatistics
Epidemiology
Social Work
Harvard Medical School
Clinical and Psychosocial Utility of Whole Exome Sequencing in Pediatric Epilepsy
Tilla Worgall, MD, PhD (PI)
Qiao Lin, PhD
Milan Stojanovic, PhD
Pathology and Cell Biology
Mechanical Engineering
Medicine
Personalized Aptamers for MRD in Multiple Myeloma