An image of two kidneys made out of puzzle pieces

Precision Medicine Pilot Award Findings Published in the New England Journal of Medicine

June 17, 2019
Kryztzstof Kiryluk

A genomic incompatibility could explain why many kidney transplants fail, even when donors and recipients are thought to be well-matched, a new study from researchers at Columbia University Vagelos College of Physicians and Surgeons suggests. The co-senior author is Dr. Krzysztof Kiryluk, Herbert Irving Assistant Professor of Medicine and Co-Director of the Irving Institute’s Precision Medicine Resource.

The genomic collision is a genetic incompatibility between kidney donor and recipient, causing the recipient to mount an immune attack against the donor protein. The findings could lead to more precise matching between donors and patients, and reduce kidney transplant failures. This publication resulted from support Dr. Kiryluk received through the 2015 Precision Medicine Pilot Award, “Donor-Recipient Genomic Incompatibilities in Solid Organ Transplant”.

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