Precision Medicine Pilot Awardees

The Precision Medicine Pilot Awards fund multidisciplinary research proposals focused on approaches to tailor medical care (prevention, diagnosis, and/or treatment) to the individual patient.

2023 Precision Medicine Joint Pilot Awaredees

Targeting S100A9 using RA antagonists and nano ligases to treat CNS metastasis in lung cancer

  • Swarnali Acharyya, PhD, Institute of Cancer Genetics (Principal Investigator)
  • Henry Colecraft, PhD, Institute of Cancer Genetics (Co-Principal Investigator)
  • Cathy Shu, MD, Med Hematology & Onc
  • Jeff Bruce, MD, Neurological Surgery
  • Guy McKhann, MD, Neurological Surgery
  • Peter Canoll, MD, PhD, Pathology & Cell Biology

The Genetic Basis of Small for Gestational Age Preterm Birth

  • Thomas Hays, MD, PhD, Pediatrics (Principal Investigator)
  • Joshua Motelow, MD, PhD, Pediatrics
  • Caitlin Baptiste, MD, Obstetrics and Gynecology

The impact of sleep fragmentation on memory dysfunctions in neuropsychiatric disorders

  • Yueqing Peng, PhD, Institute of Genomic Medicine (Principal Investigator)
  • Gergely Turi, PhD, New York State Psychiatric Institute (Co-Principal Investigator)

Metallomics MISSION: A comprehensive assessment of Metals, ISotopes and SpeciatioN as disease biomarkers and therapeutic targets

  • Kathrin Schilling, PhD, Environmental Health Sciences (Principal Investigator)
  • Ronald Glabonjat, PhD, Environmental Health Sciences (Co-Principal Investigator)
  • Ana-Navas Acien, MD, PhD, Environmental Health Sciences (Co-Principal Investigator)
  • Alex N Halliday, PhD, Columbia Climate School (Co-Principal Investigator)
  • Hiroo Takayama, MD, Surgery (Co-Principal Investigator)
  • Gervasio A Lamas, MD, Division of Cardiology at Mount Sinai Medical Center, Columbia University (Co-Principal Investigator)

Impaired cellular energetics and lipid metabolism in human iPSC-derived Cardiomyocytes carrying cardiomyopathy-causing mutations in genes encoding nuclear envelope proteins

  • Ji-Yeon Shin, PhD, Medicine (Principal Investigator)
  • Barry M. Fine, MD, PhD, Medicine
  • Hanrui Zhang, PhD, Medicine

2022 Precision Medicine Joint Pilot Awardees

The Immunopathology of Donor-Derived APOL1 Nephropathy 

  • Ibrahim Batal, MD, Pathology and Cell Biology (Principal Investigator) 
  • Kevin Gardner, MD, PhD, Pathology and Cell Biology 
  • Barry Freedman, MD, Wake Forest School of Medicine 
  • Iuliana Ionita-Laza, PhD, Biostatistics 

Optimization of Small Molecules that Restore Enzyme Activity to R152H GPX4 

  • Brent Stockwell, PhD, Biological Sciences (Principal Investigator) 
  • Farhad Forouhar, PhD, Herbert Irving Comprehensive Cancer Center 
  • Mohammed N. AlQuraishi, PhD, Systems Biology 

Study of Sleep as an Essential Factor in Aging: Analysis of Biological Biomarkers as Mediators in the Development of Cardiovascular Diseases 

  • Marie-Pierre St-Onge, PhD, Medicine/Nutritional Medicine (Principal Investigator) 
  • Lawrence Honig, MD, PhD, Neurology 
  • Rocio Barragan, PhD, University of Valencia 
  • Christian Dye, PhD, Environmental Health Sciences 
  • Bin Cheng, PhD, Biostatistics 

Towards Precision Psychiatry: An In Vitro Model of Schizophrenia-associated Network Pathophysiology 

  • Raju Tomer, PhD, Biological Sciences (Principal Investigator) 
  • Joseph Gogos, MD, PhD, Physiology and Cellular Biophysics, Neuroscience and Psychiatry 
  • Sander Markx, MD, PhD, Psychiatry 

Central Memory T cells in the Human Colorectal Cancer Immune Microenvironment 

  • Kelley Yan, MD, PhD, Medicine and Genetics and Development (Principal Investigator) 
  • Arnold Han, MD, PhD, Medicine and Microbiology and Immunology (Co-Principal Investigator) 

2021 Precision Medicine Joint Pilot Awardees

Retinal Imaging and Deep Learning to Identify Maternal Risk & Reduce Racial Disparities

  • Srilaxmi Bearelly, MD, Ophthalmology (Principal Investigator)
  • Ronald Wapner, MD, Obstetrics and Gynecology
  • Andrew Laine, DSc, Biomedical Engineering and Radiology

Patient-Derived Organoids to Model and Manipulate Tumor Regulatory Dependencies In Esophageal Adenocarcinoma

  • Brian Henick, MD, Medicine/Hematology and Oncology (Principal Investigator)
  • Andrea Califano, Dr, Systems Biology
  • Chao Lu, PhD, Genetics and Development
  • Hiroshi Nakagawa, MD, Medicine/Digestive and Liver Diseases

Direct Visualization of Malaria Parasite Invasion Using Cryoelectron Tomography

  • Chi-Min Ho, PhD, Microbiology and Immunology (Principal Investigator)
  • David Cobb, PhD, Microbiology and Immunology

Develop New Computational Methods to Predict Functional Impact of Missense Variants Based on Protein Structure Using Machine Learning

  • Yufeng Shen, PhD, Systems Biology and Biomedical Informatics (Principal Investigator)
  • Mohammed AlQuraishi, PhD, Systems Biology

A Special Ribosome in the Heart: Understanding how Mutations in Ribosomal Protein RPL3L Cause Neonatal Dilated Cardiomyopathy by Using Patient-derived iPSCs and Genetically Engineered Mice

  • Xuebing Wu, PhD, Systems Biology and Medicine/Cardiology (Principal Investigator)
  • Steven Marx, MD, Medicine/Cardiology and Pharmacology
  • Teresa Lee, MD, Pediatrics/Cardiology
  • Mythily Ganapathi, PhD, Pathology and Cell Biology

2020 Precision Medicine Joint Pilot Awardees

Biological and Therapeutic Relevance of Exosomes in Uveal Melanoma

  • Richard Carvajal, MD (Principal Investigator)
  • Alex Rai, MD
  • Grazia Ambrosini, PhD

Mechanistic Investigation of the Vaginal Microbiome in Different Manifestations of Spontaneous Preterm Birth

  • Tal Korem, PhD (Principal Investigator)
  • Anne-Catrin Uhleman, MD, PhD
  • George Gallos, MD
  • Joy-Sarah Vink, MD

A microRNA Approach to Identify Renal Osteodystrophy Sub-Type

  • Thomas Nickolas, MD, MS (Principal Investigator)
  • Stavroula Kousteni, PhD
  • Krzysztof Kiryluk, MD, MS

Deciphering Monogenic and Polygenic Etiologies of a Longitudinal Multi-Ethnic Hidradenitis Suppurativa Cohort

  • Lynn Petukhova, PhD (Principal Investigator)
  • Suzanne Leal, PhD

Unbiased Screen of Proximal and Distal Splicing Regulatory Elements Towards Drug Discovery

  • Chaolin Zhang, PhD (Principal Investigator)
  • Samuel Sternberg, PhD


2019 Precision Medicine Joint Pilot Awardees

Identification of Precision Diagnostic and Therapeutic Targets for Advanced Prostate Cancer Patients Based on Mechanistic RNA Landscape

  • Howard Lieberman, PhD, Radiation Oncology (Principal Investigator)
  • Israel Deutsch, MD, Radiation Oncology
  • Richard Friedman, PhD, Biomedical Informatics
  • Sven Wenske, MD, Urology

Application of Multi-Omics Profiling to Predict Adverse Left Ventricular Remodeling and Cardivascular Events in Hypertrophic Cardiomyopathy

  • Yuichi Shimada, MD, Medicine/Cardiology (Principal Investigator)
  • Matthew Maurer, MD, Medicine/Cardiology
  • Rajesh Soni, PhD, Medicine/Hematology and Oncology
  • Renu Nandakumar, PhD, Medicine/General Medicine
  • Kohei Hasegawa, MD, Medicine/Emergency Medicine

TBX3 as a Novel Regulator of POMC for Therapeutic Targeting 

  • Vidhu Thaker, MD, Pediatrics/Molecular Genetics (Principal Investigator)
  • Claudia Doege, MD, Pathology and Cell Biology 

2018 Precision Medicine Joint Pilot Awardees

Future Cardiovascular and Cerebrovascular Health Among Women with Severe Preeclampsia During Pregnancy and Delivery

  • Kristen Cleary, MD, Obstetrics/Gyn MFM (Principal Investigator)
  • Eliza Miller, MD, Medicine/Neurology
  • Natalie Bello, MD, MPH, Medicine/Cardiology
  • Ruth Landau, MD, Anesthesiology

Personalized Investigation of Disease Mechanisms and Prediction of Medication Responsiveness in Women with Pregnancy and Lactosis-Associated Osteoporosis

  • Adi Cohen, MD, MHS, Medicine/Endocrinology (Principal Investigator)
  • Stavroula Kousteni, PhD, Physiology and Cellular Biophysics
  • Elizabeth Shane, MD, Medicine/Endocrinology
  • Thomas Nickolas, MD, MS, Medicine/Nephrology

Understanding the Role of the Human Microbiome in Graves' Disease with and without Orbitopathy

  • Lora Glass, MD, Ophthalmology (Co-Principal Investigator)
  • Bryan Winn, MD, Ophthalmology (Co-Principal Investigator)
  • Anne-Catrin Uhlemann, MD, PhD, Medicine/Infectious Diseases
  • Stephen Tsang, MD, PhD, Ophthalmology
  • Salila Kurra, MD, Medicine/Endocrinology
  • Robert McConnell, MD, Medicine/Endocrinology

Towards a Molecular-Based Precision Medicine

  • Rosemary Sampogna, MD, Medicine/Nephrology (Principal Investigator)
  • Barry Honig, PhD, Systems Biology
  • Lawrence Shapiro, PhD, Biochemistry and Molecular Biophysics

Implementing a Health Screening App to Match People with Lower Limb Loss at High Risk for Low Function to Personalized Physiotherapy and Injury Prevention Education

  • Kevin Wong, PhD, Rehab & Regenerative Med PT (Principal Investigator)
  • Gregory Youdan, MA, Teacher's College
  • Stanford Chihuri, MS, Anesthesiology 

2017 Precision Medicine Joint Pilot Awardees

Definition of Acute Kidney Injury at Single Cell Resolution

  • Jonathan Barasch, MD, PhD, Medicine: Nephrology (Principal Investigator)
  • Peter Sims, PhD, Systems Biology
  • Krzysztof Kiryluk, MD, Medicine: Nephrology
  • Christopher Anderson, MD, Urology
  • Pablo Gonzalez-Camara, PhD, Systems Biology
  • Raul Rabadan, PhD, Systems Biology

Modeling and Prediction of Primary Graft Dysfunction After Heart Transplant

  • Barry Fine, MD, PhD, Medicine: Cardiology (Principal Investigator)
  • Gordana Vunjak-Novakovic, PhD, Biomedical Engineering
  • Emily Chen, PhD, Pharmacology
  • Emmanuel Zorn, PhD, Medicine: Cardiology
  • Paolo Colombo, MD, Medicine: Cardiology
  • Nicholas Tatonetti, PhD, Biomedical Informatics

Precision T-cell Receptor-based Cancer Therapies

  • Arnold Han, MD, PhD, Medicine: Digestive and Liver Diseases (Principal Investigator)
  • Yufeng Shen, PhD, Biomedical Informatics
  • Kelley Yan, MD, PhD, Medicine: Digestive and Liver Diseases
  • Paul Oberstein, MD, Hematology and Oncology
  • Emmanuel Zorn, PhD, Medicine: Cardiology
  • Sacher Adrian, MD, Hematology and Oncology

Patient-specific Computational Models to Guide Atrial Fibrillation Therapy

  • Vivek Iyer, MD, Medicine: Cardiology (Principal Investigator)
  • Hasan Garan, MD, Medicine: Cardiology
  • Angelo Biviano, MD, Medicine: Cardiology

A TCR Sequencing Approach to Understanding Graft Dysfunction Following Transplantation for Autoimmune Liver Disease

  • Mercedes Martinez, MD, Pediatrics: Gastroenterology, Hepatology and Nutrition (Principal Investigator)
  • Megan Sykes, MD, Hematology and Oncology
  • Elizabeth Verna, MD, Medicine: Digestive and Liver Diseases

2016 Precision Medicine Joint Pilot Awardees

Precision Delivery of c-Myc-Silencing Therapy by Identifying Genes Sensitive to Dual Inhibition of PI3Kδ and CK1ε

  • Changchun Deng, MD, PhD, Medicine (Principal Investigator)
  • Peter Sims, PhD, Systems Biology
  • Donald Landry, MD, PhD, Medicine
  • Karthik Ganapathi, PhD, Pathology and Cell Biology

Development of a Personalized Approach to the Evaluation and Treatment of Acromegaly: Integration of Genomic, Histopathologic and Radiographic Data With a Large, Existing Prospective Clinical Outcomes Dataset

  • Pamela Freda, MD, Medicine (Principal Investigator)
  • Peter Canoll, MD, PhD, Pathology and Cell Biology
  • Jeffrey Bruce, MD, Neurosurgery
  • Yufeng Shen, PhD, Biomedical Informatics
  • Zhezhen Jin, PhD, Biostatistics
  • Alexander Khandji, MD, Radiology

Precision Targeting of Pancreatic Cancer Regulatory Networks

  • Kenneth Olive, PhD, Medicine (Principal Investigator)
  • Andrea Califano, PhD, Systems Biology

A Functional Modeling Framework to Identify Actionable Alleles From Clinical Exome Sequencing

  • Simone Sanna-Cherchi, MD, Medicine (Principal Investigator)
  • Iuliana Ionite-Laza, PhD, Biostatistics
  • Barry Honig, PhD, MS, Biochemistry and Molecular Biophysics

A Genetic Approach Toward Individualizing the Assessment of Osteoporosis

  • Marcella Walker, MD, MS, Medicine (Principal Investigator)
  • David Goldstein, PhD, Genetics and Development
  • Edward Guo, PhD, MS, Biomedical Engineering
  • Xiaolin Zhu, MB, Institute for Genomic Medicine

2015 Precision Medicine Joint Pilot Awardees

Model Enrichment in Reinforcement Learning for Optimal Personalized and Patient Centered Cancer Treatments

  • Ying Kuen K. Cheung, PhD, Biostatistics (Principal Investigator)
  • Joseph Jurcic, MD, Medicine
  • Shing Lee, PhD, Biostatistics
  • Min Qian, PhD, Biostatistics
  • Gary Schwartz, MD, Medicine

Personalized Pharmacology for Neonatal Cardiac Patients at Risk for Arterial Thrombotic Events

  • Thomas Diacovo, MD, Pediatrics (Principal Investigator)
  • Samuel Sia, PhD, Biomedical Engineering

Donor-Recipient Genomic Incompatibilities in Solid Organ Transplant

  • Krzysztof Kiryluk, MD, MS, Medicine (Principal Investigator)
  • David J. Cohen, MD, Medicine
  • Vivette D. D’Agati, MD, Pathology and Cell Biology
  • Jean C. Emond, MD, Surgery
  • Susan Restaino, MD, Medicine
  • Elizabeth Verna, MD, Medicine
  • Chunhua Weng, PhD, Bioinformatics
  • Emmanuel Zorn, PhD, Medicine

A New Biomarker of Kidney Transplant Outcomes: Tracking the Fate of Donor-Reactive T Cells in the Blood and Urine

  • Heath Morris, MD, Medicine (Principal Investigator)
  • Yufeng Shen, PhD, Biomedical Informatics
  • Megan Sykes, MD, Medicine

Clinical and Psychosocial Utility of Whole Exome Sequencing in Pediatric Epilepsy

  • Ruth Ottman, PhD, Epidemiology (Principal Investigator)
  • Cigdem Inan Akman, MD, Neurology
  • Hyunmi Choi, MD, MS, Neurology
  • Arthur Jeff Goldsmith, PhD, Biostatistics
  • Dale C. Hesdorffer, PhD, Epidemiology
  • Karolynn Siegel, PhD, Social Work
  • Annapurna Poduri, MD, PhD, Harvard Medical School

Personalized Aptamers for MRD in Multiple Myeloma

  • Tilla Worgall, MD, PhD, Pathology and Cell Biology (Principal Investigator)
  • Qiao Lin, PhD, Mechanical Engineering
  • Milan Stojanovic, PhD, Medicine