Precision Medicine Pilot Awardees

The Precision Medicine Pilot Awards fund multidisciplinary research proposals focused on approaches to tailor medical care (prevention, diagnosis, and/or treatment) to the individual patient.

2019 Precision Medicine Pilot Awardees

Identification of Precision Diagnostic and Therapeutic Targets for Advanced Prostate Cancer Patients Based on Mechanistic RNA Landscape

  • Howard Lieberman, PhD, Radiation Oncology (Principal Investigator)
  • Israel Deutsch, MD, Radiation Oncology
  • Richard Friedman, PhD, Biomedical Informatics
  • Sven Wenske, MD, Urology

Application of Multi-Omics Profiling to Predict Adverse Left Ventricular Remodeling and Cardivascular Events in Hypertrophic Cardiomyopathy

  • Yuichi Shimada, MD, Medicine/Cardiology (Principal Investigator)
  • Matthew Maurer, MD, Medicine/Cardiology
  • Rajesh Soni, PhD, Medicine/Hematology and Oncology
  • Renu Nandakumar, PhD, Medicine/General Medicine
  • Kohei Hasegawa, MD, Medicine/Emergency Medicine

TBX3 as a Novel Regulator of POMC for Therapeutic Targeting 

  • Vidhu Thaker, MD, Pediatrics/Molecular Genetics (Principal Investigator)
  • Claudia Doege, MD, Pathology and Cell Biology 

2018 Precision Medicine Pilot Awardees

Future Cardiovascular and Cerebrovascular Health Among Women with Severe Preeclampsia During Pregnancy and Delivery

  • Kristen Cleary, MD, Obstetrics/Gyn MFM (Principal Investigator)
  • Eliza Miller, MD, Medicine/Neurology
  • Natalie Bello, MD, MPH, Medicine/Cardiology
  • Ruth Landau, MD, Anesthesiology

Personalized Investigation of Disease Mechanisms and Prediction of Medication Responsiveness in Women with Pregnancy and Lactosis-Associated Osteoporosis

  • Adi Cohen, MD, MHS, Medicine/Endocrinology (Principal Investigator)
  • Stavroula Kousteni, PhD, Physiology and Cellular Biophysics
  • Elizabeth Shane, MD, Medicine/Endocrinology
  • Thomas Nickolas, MD, MS, Medicine/Nephrology

    Understanding the Role of the Human Microbiome in Graves' Disease with and without Orbitopathy

    • Lora Glass, MD, Ophthalmology (Co-Principal Investigator)
    • Bryan Winn, MD, Ophthalmology (Co-Principal Investigator)
    • Anne-Catrin Uhlemann, MD, PhD, Medicine/Infectious Diseases
    • Stephen Tsang, MD, PhD, Ophthalmology
    • Salila Kurra, MD, Medicine/Endocrinology
    • Robert McConnell, MD, Medicine/Endocrinology

    Towards a Molecular-Based Precision Medicine

    • Rosemary Sampogna, MD, Medicine/Nephrology (Principal Investigator)
    • Barry Honig, PhD, Systems Biology
    • Lawrence Shapiro, PhD, Biochemistry and Molecular Biophysics

    Implementing a Health Screening App to Match People with Lower Limb Loss at High Risk for Low Function to Personalized Physiotherapy and Injury Prevention Education

    • Kevin Wong, PhD, Rehab & Regenerative Med PT (Principal Investigator)
    • Gregory Youdan, MA, Teacher's College
    • Stanford Chihuri, MS, Anesthesiology 

    2017 Precision Medicine Pilot Awardees

    Definition of Acute Kidney Injury at Single Cell Resolution

    • Jonathan Barasch, MD, PhD, Medicine: Nephrology (Principal Investigator)
    • Peter Sims, PhD, Systems Biology
    • Krzysztof Kiryluk, MD, Medicine: Nephrology
    • Christopher Anderson, MD, Urology
    • Pablo Gonzalez-Camara, PhD, Systems Biology
    • Raul Rabadan, PhD, Systems Biology

    Modeling and Prediction of Primary Graft Dysfunction After Heart Transplant

    • Barry Fine, MD, PhD, Medicine: Cardiology (Principal Investigator)
    • Gordana Vunjak-Novakovic, PhD, Biomedical Engineering
    • Emily Chen, PhD, Pharmacology
    • Emmanuel Zorn, PhD, Medicine: Cardiology
    • Paolo Colombo, MD, Medicine: Cardiology
    • Nicholas Tatonetti, PhD, Biomedical Informatics

    Precision T-cell Receptor-based Cancer Therapies

    • Arnold Han, MD, PhD, Medicine: Digestive and Liver Diseases (Principal Investigator)
    • Yufeng Shen, PhD, Biomedical Informatics
    • Kelley Yan, MD, PhD, Medicine: Digestive and Liver Diseases
    • Paul Oberstein, MD, Hematology and Oncology
    • Emmanuel Zorn, PhD, Medicine: Cardiology
    • Sacher Adrian, MD, Hematology and Oncology

    Patient-specific Computational Models to Guide Atrial Fibrillation Therapy

    • Vivek Iyer, MD, Medicine: Cardiology (Principal Investigator)
    • Hasan Garan, MD, Medicine: Cardiology
    • Angelo Biviano, MD, Medicine: Cardiology

    A TCR Sequencing Approach to Understanding Graft Dysfunction Following Transplantation for Autoimmune Liver Disease

    • Mercedes Martinez, MD, Pediatrics: Gastroenterology, Hepatology and Nutrition (Principal Investigator)
    • Megan Sykes, MD, Hematology and Oncology
    • Elizabeth Verna, MD, Medicine: Digestive and Liver Diseases

    2016 Precision Medicine Pilot Awardees

    Precision Delivery of c-Myc-Silencing Therapy by Identifying Genes Sensitive to Dual Inhibition of PI3Kδ and CK1ε

    • Changchun Deng, MD, PhD, Medicine (Principal Investigator)
    • Peter Sims, PhD, Systems Biology
    • Donald Landry, MD, PhD, Medicine
    • Karthik Ganapathi, PhD, Pathology and Cell Biology

    Development of a Personalized Approach to the Evaluation and Treatment of Acromegaly: Integration of Genomic, Histopathologic and Radiographic Data With a Large, Existing Prospective Clinical Outcomes Dataset

    • Pamela Freda, MD, Medicine (Principal Investigator)
    • Peter Canoll, MD, PhD, Pathology and Cell Biology
    • Jeffrey Bruce, MD, Neurosurgery
    • Yufeng Shen, PhD, Biomedical Informatics
    • Zhezhen Jin, PhD, Biostatistics
    • Alexander Khandji, MD, Radiology

    Precision Targeting of Pancreatic Cancer Regulatory Networks

    • Kenneth Olive, PhD, Medicine (Principal Investigator)
    • Andrea Califano, PhD, Systems Biology

    A Functional Modeling Framework to Identify Actionable Alleles From Clinical Exome Sequencing

    • Simone Sanna-Cherchi, MD, Medicine (Principal Investigator)
    • Iuliana Ionite-Laza, PhD, Biostatistics
    • Barry Honig, PhD, MS, Biochemistry and Molecular Biophysics

    A Genetic Approach Toward Individualizing the Assessment of Osteoporosis

    • Marcella Walker, MD, MS, Medicine (Principal Investigator)
    • David Goldstein, PhD, Genetics and Development
    • Edward Guo, PhD, MS, Biomedical Engineering
    • Xiaolin Zhu, MB, Institute for Genomic Medicine

    2015 Precision Medicine Pilot Awardees

    Model Enrichment in Reinforcement Learning for Optimal Personalized and Patient Centered Cancer Treatments

    • Ying Kuen K. Cheung, PhD, Biostatistics (Principal Investigator)
    • Joseph Jurcic, MD, Medicine
    • Shing Lee, PhD, Biostatistics
    • Min Qian, PhD, Biostatistics
    • Gary Schwartz, MD, Medicine

    Personalized Pharmacology for Neonatal Cardiac Patients at Risk for Arterial Thrombotic Events

    • Thomas Diacovo, MD, Pediatrics (Principal Investigator)
    • Samuel Sia, PhD, Biomedical Engineering

    Donor-Recipient Genomic Incompatibilities in Solid Organ Transplant

    • Krzysztof Kiryluk, MD, MS, Medicine (Principal Investigator)
    • David J. Cohen, MD, Medicine
    • Vivette D. D’Agati, MD, Pathology and Cell Biology
    • Jean C. Emond, MD, Surgery
    • Susan Restaino, MD, Medicine
    • Elizabeth Verna, MD, Medicine
    • Chunhua Weng, PhD, Bioinformatics
    • Emmanuel Zorn, PhD, Medicine

    A New Biomarker of Kidney Transplant Outcomes: Tracking the Fate of Donor-Reactive T Cells in the Blood and Urine

    • Heath Morris, MD, Medicine (Principal Investigator)
    • Yufeng Shen, PhD, Biomedical Informatics
    • Megan Sykes, MD, Medicine

    Clinical and Psychosocial Utility of Whole Exome Sequencing in Pediatric Epilepsy

    • Ruth Ottman, PhD, Epidemiology (Principal Investigator)
    • Cigdem Inan Akman, MD, Neurology
    • Hyunmi Choi, MD, MS, Neurology
    • Arthur Jeff Goldsmith, PhD, Biostatistics
    • Dale C. Hesdorffer, PhD, Epidemiology
    • Karolynn Siegel, PhD, Social Work
    • Annapurna Poduri, MD, PhD, Harvard Medical School

    Personalized Aptamers for MRD in Multiple Myeloma

    • Tilla Worgall, MD, PhD, Pathology and Cell Biology (Principal Investigator)
    • Qiao Lin, PhD, Mechanical Engineering
    • Milan Stojanovic, PhD, Medicine