Translational Therapeutics Accelerator Pilot Awardees

The Translational Therapeutics Accelerator (TRx) Pilot Award provides investigators with the resources to position their therapeutic discoveries for future commercial value. Awardees are expected to develop a commercially relevant product profile.

2019 TRx Pilot Awardees

Development of a Novel Beta2-blocker for Treating Pancreatic Cancer

  • Timothy C. Wang, MD, Medicine
  • Donald Landry, MD, PhD, Chair, Medicine

Programmable Bacteria for Oral Delivery of Tumor-targeted Immunotherapy 

  • Tal Danino, PhD, Biomedical Engineering 
  • Nicholas Arpaia, PhD, Microbiology and Immunology 

Inhaled Selective Serotonin Reuptake Inhibitor as a Treatment for COPD 

  • Jeanine D'Armiento, PhD, Medicine
  • Adam Gerber, MD, PhD, Anesthesiology

Validating OncoTreat, a Systems Biology Approach to Predict Drug Sensitivity, in Advanced Gastrointestinal Stromal Tumors

  • Gary Schwartz, MD, Medicine
  • Andrea Califano, PhD, Systems Biology 

Lx6171: A New Therapeutic for the Highly Disabling Negative Symptoms of Schizophrenia 

  • Catherine Clelland, PhD, Pathology & Cell Biology
  • James Clelland, PhD, Psychiatry (NYU)

Developing PI3 Kinase Inhibitors for T Cell Lymphoma 

  • Changchun Deng, MD, PhD, Medicine
  • Jennifer K. Lue, MD, Medicine

Preclinical Optimization of DNA and mRNA-based Endotope Platforms

  • Remi Creusot, PhD, Medicine
  • Magdalena Bogun, MD, Medicine

Drug Based Modulation of Endogenous Fibrocartilage Stem Cells for TMJ Regeneration 

  • Mildred Embree, DMD, PhD, Dental Medicine

A Novel CRISPR/Cas9 Based Mutation Correction Method for Hemoglobinopathies

  • Suleyman Ucuncuoglu, PhD, Biological Sciences 
  • Wendy Chung, MD, PhD, Pediatrics 

2018 TRx Pilot Awardees

MAP4K2 as a Therapeutic Target of Multiple Myeloma and Development of Novel Targeting Drugs

  • Suzanne Lentzsch, MD, PhD, Associate Professor of Clinical Medicine
  • Don Landry, MD, PhD, Samuel Bard Professor of Medicine

Engineered Deubiquitinases: A Novel Therapeutic Platform

  • Henry M. Colecraft, PhD, Associate Professor of Physiology & Cellular Biophysics
  • Alice Prince, MD, Professor of Pediatrics in Pharmacology 

Theridase: Therapy for Cerebral Edema and Increased Intracranial Pressure

  • Steve Kernie, MD, Professor of Pediatrics in Neurology
  • Barclay Morrison, PhD, Professor of Biomedical Engineering 

CalCardia: Fixing Abnormal Calcium Handling in Sick Hearts

  • Steven Marx, MD, Professor of Medicine in Pharmacology
  • Alexander Kushnir, MD, PhD, Cardiac Electrophysiology Fellow

Optimization of the Isopomiferin Scaffold as an HDAC-based Precision Medicine for MycNAMP Nueroblastoma 

  • Brent Stockwell, PhD, Professor of Biological Sciences and Chemistry
  • Darrell Yamashiro, MD, PhD, Associate Professor of Pathology & Cell Biology and Pediatrics

Injectable Cell-based Therapy of Micro-Tissues for Extremely Rapid Recovery of Ischemic Conditions

  • Samuel Sia, PhD, Professor of Biomedical Engineering
  • Danielle Bajakian, MD, Assistant Professor of Surgery 

2017 TRx Pilot Awardees

Suppression of Oncogene Transcription by PNAs as Cancer Therapy

  • Jeffrey Rothman, MD, PhD, Medicine
  • Gary Schwartz, MD, Medicine

Direct Application of Antibody Impregnated Bioengineered Patch to Improve Wound Healing in Diabetes

  • Lynne Johnson, MD, Medicine
  • Gordana Vunjak-Novakovic, PhD, Biomedical Engineering

Regulation of Appetite by the Skeleton

  • Mishaela Rubin, MD, Medicine: Physiology/Cell Biophysics
  • Stavroula Kousteni, PhD, Medicine

Using Anti-Sense Oligonucleotides as New Therapeutic Modality for Psychiatric and Cognitive Disorders

  • Joseph Gogos, MD, PhD, Physiology/Cell Biophysics
  • Sander Markx, MD, Psych Molecular Therapeutics